The Pediatric and Developmental Pathology Podcast

In this episode of the Pediatric and Developmental Pathology Podcast, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Catherine Gestrich, Pediatric and Molecular Pathologist and Director of Pediatric Molecular Pathology in the Department of Pathology at UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, and Dr. Qian Wang, Pediatric Pathologist and Cytopathologist, also in the Department of Pathology at UPMC Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine.

Hear how an incidental pancreatic mass in a young patient led to a diagnostic puzzle, and how chromosomal microarray and next-generation sequencing uncovered a never-before-reported NRAS mutation alongside TP53 alterations and numerous copy number changes in a case of pancreatoblastoma. We also discuss UPMC's approach to molecular testing across adult and pediatric tumors, the Molecular Characterization Initiative for rare pediatric cancers, and their article in Pediatric and Developmental Pathology:

Pediatric Pancreatoblastoma with an NRAS Mutation: Expanding the Spectrum of Genetic Alterations in Pancreatoblastoma

Featured public domain music: Summer Pride by Loyalty Freak

In this episode of the Pediatric and Developmental Pathology Podcast, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Tetyana Nesterenko, Neonatologist in the Division of Neonatal-Perinatal Medicine at UT Southwestern Medical Center, affiliated with Dallas Children's Hospital; Dr. Evelyn Ilori, Hematopathology Fellow at UT Southwestern; Dr. Christine Kahlow, PGY-3 Resident at UT Southwestern; and Dr. Charles Timmons, Pediatric Pathologist and faculty at UT Southwestern, based at Children's Medical Center.

Hear how a multidisciplinary team at UT Southwestern approached a full-term neonate's unexplained, rapidly fatal respiratory failure, from the resuscitation and family communication in the NICU to an autopsy that uncovered severe pulmonary hypoplasia and congenital alveolar dysplasia. A standard genetic sequencing panel came back normal, but chromosomal microarray analysis revealed the true cause: a deletion encompassing the TBX4 gene. We discuss the collaboration of their team to identify TBX4 haploinsufficiency at autopsy, and their article in Pediatric and Developmental Pathology:

Primary Pulmonary Hypoplasia With Congenital Alveolar Dysplasia Associated With TBX4 Gene Deletion: A Case With Autopsy and Molecular Findings

Featured public domain music: Summer Pride by Loyalty Freak

In this episode of the Pediatric and Developmental Pathology Podcast, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Sanjita Ravishankar, a Pediatric, Perinatal, and Gynecologic Pathologist at University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, who led the Society for Pediatric Pathology's Placental Pathology Reporting Task Force; Dr. Philip Katzman, a Pediatric and Perinatal Pathologist at the University of Rochester Medicine; Dr. Karen Mestan, Professor of Pediatrics and Division Chief of Neonatology at the University of California San Diego and Rady Children's Hospital; and Alicia Loehlein, co-founder of the nonprofit organization Measure the Placenta (@measuretheplacenta).

Hear how a multidisciplinary task force of the Society for Pediatric Pathology (@SocPediPath), including pathologists, obstetric and neonatology clinicians, and patient advocates worked together to build a standardized placental pathology reporting template designed to complement the Amsterdam consensus definitions as we discuss their article in Pediatric and Developmental Pathology:

Standardized Placental Pathology Reporting: Improving Quality and Clinical Utility Recommendations From the Society for Pediatric Pathology Placental Pathology Reporting Task Force

Learn more about the patient advocacy work discussed in this episode:

Measure the Placenta: measuretheplacenta.org | Instagram: @measuretheplacenta

 

Featured public domain music: Summer Pride by Loyalty Freak

In this special episode of the Pediatric and Developmental Pathology Podcast, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Bev Rogers of the University of Arizona and Banner Health, Dr. Raj Kapur of Seattle Children's Hospital, Dr. Linda Ernst of Endeavor Health and the University of Chicago, and Dr. Miguel Reyes-Múgica of the University of Miami and Holtz Children's Hospital.

Hear about the Perspectives In Pediatric Pathology series from the history of Perspectives In Pediatric Pathology and how it became part of Pediatric and Developmental Pathology, to the current issue of Perspectives featuring articles on fetal and placental pathology for the general pathologist in Pediatric and Developmental Pathology:

Perinatal Pathology for the General Pathologist - A Practical Guide to Fetal and Placental Examination

 

Featured public domain music: Summer Pride by Loyalty Freak

In this episode of the Pediatric and Developmental Pathology Podcast, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Sonja Chen (X: @IslandJewelsena, LinkedIn: Sonja Chen and Instagram: @pediatricpathologyadventurer), Director of Autopsy Services and Program Director for the Pediatric Anatomic Pathology Fellowship at Nationwide Children's Hospital and Dr. Oscar Lopez-Nunez (@olopeznu), Pediatric Pathology Fellowship Program Director at Cincinnati Children's Hospital.

 

Hear how social media has shaped careers, collaborations, and the visibility of pediatric pathology, as well as what the field stands to gain by embracing Social Media more fully, as we discuss their article in Pediatric and Developmental Pathology:

 

Exploring the Impacts and Prospects of Social Media in Advancing Pediatric Pathology

 

Featured public domain music: Summer Pride by Loyalty Freak

In this episode of the Pediatric and Developmental Pathology Podcast, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Peilin Zhang, a Pathologist at Sharp Memorial Hospital in San Diego, California.

Hear how building a database of placental pathology information led to the identification of unexpected correlations, and the article in Pediatric and Developmental Pathology:

Intervillous Thrombus Is Independently Associated With Placental Infarct and Single Umbilical Artery as well as Fetal Inflammatory Response: Implication of Fetal Vascular Flow in Pathogenesis

 

Featured public domain music: Summer Pride by Loyalty Freak

In this episode of the Pediatric and Developmental Pathology Podcast, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Manas Kalra, a Pediatric Oncologist in the Department of Paediatric Haematology Oncology and BMT at Sir Ganga Ram Hospital in New Delhi, India and Dr. Neha Bakshi, a Histopathologist in the Department of Pathology, Histopathology Division, of Sir Ganga Ram Hospital in New Delhi, India.

Hear how a multidisciplinary approach identified a paratesticular presentation of a rare tumor, and their resulting article in Pediatric and Developmental Pathology:

“What the Mind Does Not Know, the Eye Does Not See”: Epididymal Melanotic Neuroectodermal Tumor of Infancy Misdiagnosed as Paratesticular Rhabdomyosarcoma—A Rare Case Report

 

Featured public domain music: Summer Pride by Loyalty Freak

In this episode of the Pediatric and Developmental Pathology Podcast, our hosts Dr. Mike Arnold (@MArnold_PedPath) and Dr. Jason Wang speak with Dr. Aida Glembocki, a Pediatric Pathologist and Masters Degree candidate at the University of Toronto, and Dr. Robert Siddaway, an Oncology Investigator at The Hospital for Sick Children in Toronto.

 

Hear about how The Hospital for Sick Children applies RNA sequencing in pediatric cancer diagnosis to reduce costs and identify key information for diagnostic classification. We also hear about their article in Pediatric and Developmental Pathology:

Fusion-Negative Rhabdomyosarcoma: Clinical Application of Targeted RNA Sequencing

 

Related article:

Siddaway R, Glembocki AI, Arnoldo A, Staunton J, Liu APY, Yuki KE, Yu M, Cohen-Gogo S, Shlien A, Villani A, Whitlock JA, Hitzler J, Tabori U, Levine AB, Lafrenière A, Nagy A, Chen H, Ngan BY, Somers GR, Abdelhaleem M, Chami R, Hawkins C. Clinical utility of targeted RNA sequencing in cancer molecular diagnostics. Nat Med. 2025 Oct;31(10):3524-3533. doi: 10.1038/s41591-025-03848-8. Epub 2025 Jul 17. PMID: 40676318.

 

Featured public domain music: Summer Pride by Loyalty Freak